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Introduction The global water cycle faces unprecedented anthropogenic stress, with aquatic ecosystems increasingly serving as the ultimate sinks for a vast array of contaminants originating from the technosphere.14 The relentless expansion of industrialisation and intensive agriculture discharges a complex mixture of chemical stressorsranging from heavy metal cations (e.g., Cd2+, Hg2+, Pb2+) to bioactive micropollutantsposing a profound threat to ecological stability.57 Legacy water treatment infrastructures are fundamentally ill-equipped to eliminate these recalcitrant contaminants, which often persist at trace concentrations (ng L1 to g L1) yet exert potent biological effects

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Rand DA (2008) Mapping global sensitivity of cellular network dynamics: sensitivity heat maps and a global summation law

Available from: February 18, 2015