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Inhibiting TGF- could reduce fibrosis but may interfere with its protective roles in resolving inflammation and promoting tissue repair, leading to unintended consequences.93 94 Therefore, therapeutic approaches targeting TGF- must be carefully considered and finely tuned to balance its profibrotic and anti-inflammatory effects

Metformin is typically administered orally, in the form of tablets or capsules

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The effect of reactive astrogliosis after acute injury depends on the presence of the ischemic penumbra and differs between the immature and adult CNS