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however, some studies have demonstrated limited benefits of intensive glycemic control for T2D patients as only modestly prevents or delays the progression of DPN and CAN in patients with T2D, possibly because of undiagnosed hyperglycemia and multiple combined risk factors

10.1016/j.pharmthera.2020.107798 114 SuX.LiuK.XieY.ZhangM.WuX.ZhangY.et al (2021)

& Birringer, M

GPx2 is expressed predominantly in the gastrointestinal tract and is considered the first protective barrier against the absorption of hydroperoxides from processed food

Briefly, cells were seeded in 96-well plates and treated with standard culture medium or conditioned medium (50 L of fresh standard culture medium and 150 L of conditioned medium) at pH 6.5 for 48 h