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Preclinical studies have elucidated multiple direct anti-atherogenic mechanisms of GLP-1 RAs, including suppression of pro-inflammatory cytokine production (TNF-, IL-1, IL-6) in macrophages, inhibition of monocyte adhesion to endothelial cells through downregulation of adhesion molecules, reduction of oxidized LDL-induced foam cell formation, and attenuation of atherosclerotic plaque development in murine models ( SGLT2i also demonstrate anti-atherosclerotic effects

Animal experiment design Eight-week-old male C57BL/6 mice were procured from the Dashuo Experimental Animal Center (Chengdu, China)

J Agric Food Chem 68(45):1258512594

All animals were housed at room temperature under a 12/12 h light/dark cycle and had free access to food and water

The addition of the AHK-Cu complex may potentially have stimulated the proliferation of normal dermal fibroblasts and possibly enhanced their viability