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Confusingly enough, cuprizone also does not kill oligodendrocytes in vitro [111], suggesting that cuprizone alone might not be enough to induce oligodendrocyte cell death in vivo

Due to the complexity of serotonin's role in migraine, further study is needed to fully characterize the effects of modulating serotonin levels and/or signaling in migraine patients

Advances in lipidomics, AI-driven receptor prediction, and structural biology are expected to accelerate the discovery of novel PRLMs and their receptors, while also providing deeper insights into their metabolic regulation [44]

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Unfortunately, this only compounds the effects