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Its targeted mechanism working on specific receptor pathways rather than broadly makes it a precise and lower-risk approach compared to systemic hormone therapy in most contexts

19 has reported that in chronic lymphocytic leukaemia, HGF secreted by mesenchymal cells not only stimulates leukaemic cell proliferation but also drives monocytes/macrophages to an M2, immune suppressive phenotype

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Specifically, while light chains of IgG2, IgG3, and IgG4 pair to the CH1 domain of their corresponding HCs through a disulfide bridge between cysteine-214 of the light chain and cysteine-127 at the N-terminus of the CH1, the corresponding pairing in IgG1 occurs with cysteine-233 at the C-terminus of CH1 [258]