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As previously mentioned, SAM, a derivative of methionine, is an essential methyl donor that serves as a substrate for DNMTs (Bekdash 2023)

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Risk of dementia associated with psychotic disorders in later life: the health in men study (HIMS)

This pathway is intimately linked to the transmethylation pathway via homocysteine, which can be remethylated to generate methionine or be irreversibly converted to cysteine (Figure 1)