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The progression of diabetes and, consequently, prolonged exposure to this condition, favor the development of secondary complications of DM

It stimulates insulin secretion, suppresses glucagon, slows gastric emptying, and acts on hypothalamic circuits to reduce appetite

It is not surprising that a wide range of genes, including ferritin [71-72], collagen [73], and transcription factors such as CREB [74] and STAT3 [75], along with AMPK [76] and several proto-oncogenes [77], are transcriptional activated in response to increased cellular oxidation

Uslaner, J., Kalechstein, A., Richter, T., et al

While Nfr2 and HO-1 are recognized inhibitors of NF-B, this specific mechanism was not discussed in the study (Dang et al., 2022)