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First, the vast majority of available data derives from animal studies, and extrapolation to human applications may not be straightforward due to species differences in physiology and drug metabolism

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As expected, BM ADO concentrations showed substantial inter-patient variability, consistent with previous reports describing wide fluctuations among MM patients ( Table 2 Individual patient values for ADO and INO concentrations in bone marrow and peripheral blood at baseline (pre-start) and at DARA treatment failure

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I went to the ER on May 9th, got another MRI and it was clear