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Autophagy in cancer: moving from understanding mechanism to improving therapy responses in patients

Key gaps to address: dose-response in humans, safety/tolerability profiles across populations, interaction effects in stacks, and long-term cardiometabolic outcomes

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2 Glial migration and synapse formation B12 regulates signaling pathways that guide the organization of neural cells and the formation of synapses, ensuring neurons establish proper connections

Our experts integrate QSAR, read-across, and weight-of-evidence approaches to evaluate data-poor substances and define defensible Permitted Daily Exposure (PDE) values in line with EMA, FDA and ICH Q3D requirements