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In addition, serum levels of endotoxin, IL-6, IL-8, and IL-10 were significantly elevated in patients with stage I-IV CKD, while intestinal occludin and claudin-1 exhibited significant reduction in expression

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Initial digestive changes appear within 2-4 weeks, while hormonal symptoms including PMS, mood swings, and cycle regularity improve after 8-12 weeks of supplementation