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The nature of the cholinergic hypothesis is based on the suppressed synthesis of the neurotransmitter acetylcholine and therefore the therapeutic intervention is based on the restoration of the physiological level of acetylcholine by inhibiting the activity of enzyme acetylcholinesterase (AChE) (Bartus et al

Comprehensive invasive and noninvasive approach to the right ventricle-pulmonary circulation unit: state of the art and clinical and research implications