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Dual angiopoietin-2 and VEGFA inhibition elicits antitumor immunity that is enhanced by PD-1 checkpoint blockade

Aside from vegetarians, people at risk for a deficiency include those with pernicious anemia, people who have had intestinal surgery such as gastric bypass, those with Crohns or celiac disease, and anyone whose stomach does not produce enough hydrochloric acid to absorb the vitamin B12 thats naturally present in food

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Withhold Pemetrexed Injection in patients with a creatinine clearance of less than 45 mL/minute [see Dosage and Administration (2.3)]