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ERK5 is a known weak client of Hsp90, and prolonged occupancy of the N-terminal ATP-binding pocket by potent inhibitors such as ganetespib or by HLX itself destabilizes a subset of Hsp90 clients, including ERK5 [48,49,50]

538 Aged astrocytes indeed express fewer glutamate transporters, resulting in age-dependent decreases in glutamate clearance

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Sharp, Ph.D., professor of physiology & biophysics and of ophthalmology and visual sciences and professor in the Dominick P