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Studies show that approximately 1% of a high-dose B12 supplement is absorbed through passive diffusion along the entire gastrointestinal tract, completely bypassing the need for Intrinsic Factor or perfect stomach acid levels

Reported concerns include local injection reactions, potential immunogenicity from copper exposure with chronic use, and theoretical risks if peptides activate unintended growth pathways

Common reasons for deficiency include: Low intake particularly diets low in whole grains, legumes, leafy greens or animal products Gut health issues like low stomach acid, SIBO, coeliac disease, IBD, or other factors affecting absorption Medications such as the contraceptive pill, metformin or antacids, which can deplete B vitamins Chronic stress increases demand for certain b vitamins, including B5 and B6 Vegan or vegetarian diets higher risk of B12 deficiency, which can be corrected through supplementation Genetic reasons some mutations on certain genes can increase a persons need for B vitamins This is why I always recommend testing before supplementing

If your issue is specifically Achilles-related, our TB-500 dosage guide covers dosing for that compound directly

G., & Shukitt-Hale, B