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Cel Biol 97 (4), 437445

The Institute of Medicine (IOM) has not established a UL (Upper Limit) for vitamin B12 because of its low potential for toxicity

Further investigation showed that CPs first reduce the level of skin oxidation, inhibit the expression of the key transcription factor AP-1 (c-Jun and c-Fos), then activate the TGF-/Smad signaling pathway to promote collagen synthesis, inhibit the expression of MMP-1/3 to inhibit collagen degradation, and inhibit skin inflammation to alleviate skin aging in mice