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Weighted gene co-expression network analysis (WGCNA) identified genotype-driven, rather than treatment-driven, gene modules, highlighting distinct transcriptional architectures between WT and KO animals

Animal studies demonstrate that BPC-157 administration following induced injury results in measurably lower inflammatory marker levels compared to untreated control groups

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[7] However, the use of GLP-1 agonists during pregnancy and lactation is less well understood, as these groups are typically excluded from clinical trials

Unlike corticosteroid injections (which reduce pain short-term but damage cartilage long-term), BPC-157 appears to be cartilage-sparing and potentially cartilage-supportive making it relevant for early-stage osteoarthritis or post-injury joint degradation