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Glutathione peroxidase 1 and glutathione are required to protect mouse astrocytes from iron-mediated hydrogen peroxide toxicity

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61 HassanA.ErianM.SaidF.SorensenK.SippelJ

The production of ROS by pyocyanin leads to oxidative stress in bacterial, fungal, and mammalian cells which causes several negative effects including a decrease in NADPH levels, inhibition of essential enzymes, DNA damage, disruption of membrane potential, oxidative damage of the components involved in cell cycle and its regulation (Abdelaziz et al

This may include a randomized controlled trial with four arms instead of two: (i) ocular hypertension with no glaucoma, (ii) high-tension glaucoma, (iii) normotensive glaucoma and (iv) healthy controls