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J., Stopeck, A., Maskarinec, G., Altbach, M., Chalasani, P., & Thompson, P

GSH-Cys adducts may be reduced by glutaredoxins (Grxs), which are homologs to Trxs (Martin, 1995), and share similar binding modes of the protein substrate with Trxs

The antioxidant enzymes (SOD, CAT and GPD) and antioxidant chemicals (vitamin E, K, C, amino acids, carotenoids, and peptides) produced by host organisms mitigate environmental and other stresses

doi: 10.1016/j.csbj.2021.02.009 106 ChangCCChangTCKaoSCKuoYFChienLF

For the polyglutamylation to be effective and to achieve tissue retention, 5-methyl-THF needs to be first metabolized to THF via the methionine cycle