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Ribulose-5-phosphate is a pivotal intermediate that can either be used for nucleotide biosynthesis or converted back into glycolytic intermediates, thus linking the PPP and glycolysis

Multiple factors contribute to mitochondrial complex I dysfunction, affecting energy metabolism and exacerbating oxidative stress, which damages neurons, and PINK1/Parkin-mediated mitochondrial autophagy is disturbed by mutations in PD-associated genes and aberrant expression of deubiquitinating enzymes, imbalances in mitochondrial dynamics, and aberrant interactions with other organelles, which all contribute to the progression of PD [159]

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The BQZ water extract significantly decreased the mRNA level of TNF-, while the BQZ BU extracts suppressed that of IL-1