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It should not be expected to reverse severe osteoarthritis, regrow advanced cartilage loss, correct major joint deformity, heal a complete tendon rupture without appropriate orthopedic management, or replace surgery when surgery is clearly indicated

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The safety in the treatment of healing of EE in adults was assessed in four randomized comparative clinical trials, which included 1,240 patients who received NEXIUM 20 mg once daily, 2,434 patients on NEXIUM 40 mg once daily, and 3,008 patients on omeprazole 20 mg once daily