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This approach has been successfully translated into the clinic as the administration of low-dose IL-2 in patients with cGvHD resulted in great responses owed in part to the promotion of thymic differentiation and peripheral expansion, survival and function of nTregs [49, 50]

Among these, the activating transcription factors (ATFs) have emerged as pivotal integrators of immune and metabolic cues, orchestrating macrophage responses under diverse physiological and pathological conditions

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A.TungkumW.CaoZ.FlemingB.et al (2022)

Liposomal glutathione has better absorption but is significantly more expensive and the evidence base is less robust than for the precursor approach