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265,266 Moreover, the Cu chelator TTM has also been evaluated in several clinical trials

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The anti-apoptotic effect is more robust than the proliferative effect

In turn, enhancing KCC2 activity not only potentiated L838,417-induced analgesia, it rescued its analgesic potential at high doses, revealing a novel strategy for analgesia in pathological pain, by combined targeting of the appropriate GABA A R-subtypes and restoring Cl - homeostasis

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