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Statistics Experiments were planned as 2 2 factorial designs, with data subject to mixed linear model analysis in R (version 4.2.1) and tests for the impact of NMN treatment within chemotherapy or vehicle control calculated by estimated marginal means using base R and the package emmeans (version 1.8.0), with p -values then subject to a Bonferroni correction for multiple comparisons

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In addition, mGluR5 inhibition rescued autistic phenotypes in mouse models of ASD