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Tumor cells heavily rely on Gln to counteract oxidative stress, yet recent studies demonstrate that glutamine deprivation or treatment with the glutamine analog DON induces epigenetic remodeling via trimethylation of histone H3K4me3, selectively upregulating HMOX1 transcription while inhibiting the activity of system Xc- subunit SLC7A11 and GPX4, thereby promoting lipid peroxidation-derived ROS accumulation and ultimately triggering ferroptotic cell death [63]

PMID: 33181153 6 Clinical features and genotyping of patients with primary carnitine deficiency identified by newborn screening

Pentadecapeptide BPC 157 resolves Suprahepatic occlusion of the inferior caval vein, Budd-Chiari syndrome model in rats

Antenatal NAC administration was associated with prolonged pregnancy and reduced neonatal morbidity in pregnancies at risk of preterm delivery

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