labial melanotic macula

labial melanotic macula macule. Benign. Dark spot on labia (or lip). Analogous to lentigo simplex. Hyperpigmented basal keratinocytes & dermal melanophages. Slight ⬆️ in single basal melanocytes; NO nests. More info like this in labial melanotic macule upper lip

Name: labial melanotic macula macule. Benign. Dark spot on labia (or lip). Analogous to lentigo simplex. Hyperpigmented basal keratinocytes & dermal melanophages. Slight ⬆️ in single basal melanocytes; NO nests. More info like this in labial melanotic macule upper lip
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labial melanotic macule upper lip a Melanotic macule at the wetdry line of the lower lip. b Melanotic An oral melanotic macule is a harmless dark spot found on the lip, most often the lower lip, or inside the mouth, either on the gums, inside the cheek, or on the roof of the mouth. An oral melanotic Oral pathology: Noting a pigmented macule that often presents a diagnostic dilemma Registered Dental Hygienists Simple cryosurgical treatment of the oral melanotic macule ScienceDirect Labial melanotic macule, dermoscopy Stock Image C060 6920 Science Photo Library

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However, the development of ex vivo slice culture models has provided an alternative model that bridges the gap between in vitro and in vivo models, enabling the investigation of demyelination and remyelination under controlled conditions, with the added advantage of reduced cost and ethical considerations (Humpel, 2015)

10.1016/j.neuroscience.2004.07.003 Neuroscience 21 BurchM

Mechanistically, this interaction is theorized to involve G-protein coupling, second messengers such as cAMP and IP3, and activation of protein kinases that regulate cellular signaling cascades