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If lifestyle measures are insufficient , your GP may recommend: Osmotic laxatives (such as macrogol) are often recommended as first-line treatment for chronic constipation Bulk-forming laxatives (such as ispaghula husk) may be suitable when stools are small and hard, particularly with IBS-like symptoms Stimulant laxatives (such as senna or bisacodyl) for short-term use in resistant cases According to NICE Clinical Knowledge Summaries , laxatives should be used appropriately and reviewed regularly

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Research suggests 5-Amino-1MQ supports fat loss without sacrificing muscle, improves mitochondrial function, and may reverse some metabolic effects of aging in cell and animal studies

Dec 2012;12(2):323-8