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Theabrownin from Pu-Erh Tea Attenuates Hypercholesterolemia via Modulation of Gut Microbiota and Bile Acid Metabolism

The two primary mechanisms of T2DM pathogenesis are pancreatic -cell dysfunction and insulin resistance

doi: 10.1016/j.beem.2009.08.013 19 FarebrotherJZimmermannMBAnderssonM

This mTOR-driven anabolic shift, while adaptive in peripheral nerves, exhibits divergent outcomes in the central nervous system, where chronic mTORC1 activation in astrocytes drives pathological lipid synthesis and droplet accumulation via DGAT1/PLIN2 upregulation, directly linking mTOR to maladaptive glial reactivity and impaired recovery in chronic stroke phases [35, 189]