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Other metabolic pathways that may be involved in the metabolism of trazodone have not been well characterized

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A post-hoc analysis suggested that oral lipoic acid supplementation may reduce neuropathic symptoms particularly in subjects with a high burden of cardiovascular disease, diabetes, and neuropathy yet with normal body mass index (BMI) and blood pressure (79)

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It also modulates inflammatory signaling, reducing excessive inflammation that can impair healing while maintaining the beneficial inflammatory signals needed to recruit stem cells and initiate repair