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ZaricBLRadovanovicJNGluvicZStewartAJEssackMMotwalliOet alAtherosclerosis linked to aberrant amino acid metabolism and immunosuppressive amino acid catabolizing enzymes

10.1371/journal.pone.0007063 PLoS One 57 DrossmanD

One of the key strategies for addressing oxidative stress is to lower the reactive oxygen species creation in the mitochondrion which is one of the main sites of their generation by using antioxidants, where they prevent oxidants from transferring electrons to other molecules

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FAP-CAR-Ms and FAP-CAR-ZETA-Ms derived from bone marrow inhibited activation of FAP-positive hepatic stellate cells in vivo , promoting extracellular matrix degradation via downregulation of Col1a1 and Acta2 and upregulation of MMP-9 and MMP-13 (89)