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Mainly, CYP3A11 and CYP3A13 metabolize TAC, along with an ATP-dependent drug efflux pump (ABCB1) that facilitates its excretion from the gut to the liver for further metabolism

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Several compounds that can modulate ferroptosis pathways have been approved by the US Food and Drug Administration (FDA) for other indications, including DFO, deferasirox (DFX), sulfasalazine (SAS), and altretamine, for treating cancers and autoimmune diseases

In addition to hosts' alcohol-metabolizing enzymes, the gut microbiota plays a role in alcohol metabolism