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Astrocytic urea cycle detoxifies Abeta-derived ammonia while impairing memory in Alzheimers disease

It's associated with an increased risk of AMD due to oxidative pathways and reduced intake of protective nutrients like Zn and vitamins

The increased Bax/Bcl-2 ratio promotes mitochondrial outer membrane permeabilization and cytochrome c release, leading to the activation of caspase-9 and downstream executioner caspase-3 (78)