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S.Castelo-Branco DdeS.SouzaE

doi: 10.1007/s00204-023-03562-9 12 JuchnowiczDDzikowskiMRogJWaszkiewiczNZalewskaAMaciejczykMet al

It is worth noting that the derivation of HBGVs applies extrapolation factors (also termed safety factors) to account for toxicodynamic and toxicokinetic differences between species and inter-individual variability in humans