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when administered by intranasal means is about 6080%

doi: 10.1016/j.exger.2020.110842 36

You should expect gradual, modest changes instead of dramatic transformations

Clive D, Johnson KO, Spector JFS, Batson AG, & Brown MMM (1979) Validation and characterization of the L5178Y/TK+/-mouse lymphoma mutagen assay system