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According to FDA trial data, only 11.2% of patients discontinued due to side effects, meaning 88.8% tolerated treatment successfully through 48 weeks

Rash and/or peeling skin, often between the chest and legs and in the genital or groin area Swelling and redness in hands and bottoms of feet Red eyes Swollen glands, especially in the neck Irritated throat, mouth, and lips Swollen, bright red strawberry tongue In the second phase, symptoms include: Joint pain Belly pain Stomach trouble, such as diarrhea and vomiting Peeling skin on hands and feet Kawasaki disease can cause heart trouble 10 days to 2 weeks after symptoms start

Such a multimodal strategy will facilitate the transition from mechanistic insights to the identification of measurable predictive biomarkers

Nat Commun 15:6718

JoAnn Manson, chief of the division of preventive medicine at Brigham and Womens Hospital in Boston and professor of medicine at Harvard Medical School