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Further mechanistic investigations determined that the elevation of intracellular GSSG levels resulted in NF-B inhibition by facilitating glutathionylated IKK- (IKK--SSG) formation, leading to enhanced TNF hepatotoxicity

Targeting beta-catenin signaling to induce apoptosis in human breast cancer cells by z-Guggulsterone and Gugulipid extract of ayurvedic medicine plant Commiphora mukul

The use of different moieties has been extensively discussed in other works and goes beyond the scope of the present paper (Blanco et al., 2015)

Knockdown of BCAT1 causes accumulation of -KG, promoting EGLN1-mediated HIF1 protein degradation and leukemia-initiating arrest (Raffel et al., 2017)

The plasmid plSAM-FVpE was confirmed by restriction enzyme digestion and gene sequencing ( Supplementary Figure 2C )