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doi:10.1038/nn1885

Collectively, viniferins demonstrate pleiotropic pharmacologic activities by defined molecular mechanisms and quantifiable dose-dependent effects

(Min to max with median, n = 68/group.) ( G ) After infection, Cyb5r3 SPCKO mice show higher levels of osteopontin by transcript ( Spp1 mRNA) in total lung lysate and secreted protein in bronchoalveolar lavage fluid

2016 Apr 23;387(10029):1723-31

Respiratory Tissue Repair and Protection COPD fibroblast restoration occurs at 10 nanomolar concentration, restoring lung fibroblasts ability to contract and restructure collagen while elevating integrin beta 1 expression