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As an adjunct to diet and exercise, Mounjaro (tirzepatide) improves glycemic control in adults with type 2 diabetes

The Food and Drug Administration does not require a significant HbA1c reduction for drug approval, leading to less effective medications entering the market []

Conflict-of-interest disclosure Norbert Gattermann: Research funding by Takeda

Functions include direct ROS/RNS scavenging, control of cellular redox potential, and Phase II detoxification via GST-mediated conjugation (e.g., of NAPQI) to facilitate biliary/urinary excretion [114, 115]

Given the lack of significant sex-based differences and the limited sample sizes within subgroups, all comparisons were performed using disease status as the primary variable to preserve statistical power and maintain analytical robustness