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Indeed, mucosal GSH depletion for a prolonged period of time (35 days) induced by diverse agents, such as BSO or DEM, results in severe degeneration of intestinal mucosal epithelial cells (Martensson et al, 1990

Mol Cell Neurosci 23(3):440450 Qian Z, Li Y, Guan Z, Guo P, Zheng K, Du Y, Yin S, Chen B, Wang H, Jiang J, Qiu K, Zhang M (2023) Global, regional, and national burden of multiple sclerosis from 1990 to 2019: findings of global burden of disease study 2019

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Under physiological conditions, HMGB1 resides predominantly in the nucleus, where it binds chromatin to regulate DNA replication, repair, and transcription

2002;69Suppl 1:SI319