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Another antagonist of MC1R, undecylenoyl phenylalanine, also induced significant lightening of pigmented lesions when applied twice daily at 2% in patients with melasma or SL [118, 119]

To evaluate the actual importance of the individual metabolites, the spectral regions highlighted in the S-line plot were quantified by Chenomx NMR Suite 7.1

5 Concluding remarks and future perspectives Many dogmas have been overturned and refined since the discovery of oncogenic metabolic alterations and the rediscovery of the roles played by glutamine and glucose in cancer cell proliferation

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