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T reg cells contribute to immunosuppression through cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) signaling, the production of TGF- and IL-10, and the conversion of ATP to adenosine via CD39 and CD73 [37]

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YAP1 over-expression in Saccharomyces cerevisiae enhances glutathione accumulation at its biosynthesis and substrate availability levels

However radiolabeled agents do not provide information regarding enzyme activity as they accumulate at the tumor site by diffusion, and the utility of fluorescent probes is limited by the depth of fluorescent light penetration through the skull