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when CBS is pharmacologically inhibited or silenced, the cellular H 2 S generation is diminished

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Hepcidin expression is affected by many factors, including serum and liver iron stores, erythropoiesis, hypoxia, inflammation and infection (157)

However, many of these inhibitors, such as RSL3 and ML162, have exhibited suboptimal pharmacological properties in preclinical animal models, while others like BSO and auranofin have not yielded the desired anti-cancer effects in clinical trials, limiting their potential for clinical translation or application