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Furthermore, selective inactivation of Fto in the hypothalamus, a key site for the nutritional regulation of Fto expression, results in reduced food intake and body weight gain

For such prospective melanogenesis inhibitors, further in vitro/in vivo studies and clinical trials are required to evaluate efficacy and safety

Ogasawara, Y., Ishii, K., Togawa, T

Tetrahydrobiopterin Concentrations in Normal and Coronary Artery Diseased Heart Tissue

54% of patients were also found to exhibit depressive symptoms in a study of the prevalence of psychiatric comorbidities in subjects with mitochondrial cytopathies (Feng et al., 2020), suggesting that targeting mechanisms of mitochondrial dysfunction may be a possibility for developing new treatments for depression