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Integrative Medicine: A Clinician's Journal, 13 (1), 8

Unlike HER1 and HER4, which possess intrinsic kinase activity and can activate downstream pathway through homo- or heterodimerization with HER2, HER3 lacks such intrinsic kinase activity and depends entirely on dimerization with HER2 for downstream signaling activation [46]

Chronic inflammation, often driven by persistent infections, autoimmune diseases, or environmental factors, can create a pro-tumorigenic environment [110]