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Mechanistically, in antioxidant activity, as a potent antioxidant, CoQ10 activates the Kelch-like ECH-associated protein 1 (KEAP1)/Nrf2/ antioxidant response element (ARE) signaling pathway, upregulating the expression and enhancing the activity of downstream antioxidant enzymes such as SOD, NQO1, and HO-1

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In addition, dihydroartemisinin promoted farnesoid X receptor (FXR) and decreased cholesterol 7 -hydroxylase (CYP7A1) and YAP1, thus inhibiting bile acid metabolism in HCC

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It seems likely that a momentary protonation event then triggers electron transfer, thereby generating a Fe(III)-OOH species, which ultimately decomposes to Fe(III) and H 2 O 2