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PD-1 is highly expressed in infiltrating lymphocytes in various tumors, and PD-1 ligands are often upregulated on the surfaces of tumor cells and inhibit the local antitumor immune response mediated by T cells (159)

De ChiaraBSeddaVParoliniMCampoloJDe MariaRCarusoRet al

Alterations in the concentration of iron have been observed in amyotrophic lateral sclerosis, spastic paraplegia, and multiple sclerosis which strengthens the knowledge that the accumulation of iron is a secondary factor that is related to neurodegenerative diseases

ROS and redox signaling in the response of plants to abiotic stress

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