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Review 10.1016/j.jdermsci.2012.11.002 [DOI] [PubMed] [Google Scholar] 95.Wang G., Siow Y.L

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The mutagenized selected library members are then shuffled by in vitro and/or in vivo recombinatorial shuffling as disclosed herein

To increase the specificity of ABT263, the proteolysis-targeting chimera (PROTAC) platform was used for modification to generate three dual BCL-xL and BCL-2 inhibitors, PZ15227, 374 753b, 375 and WH244