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With a molecular weight of just 403.93 Da well below the 500 Da cutoff typically associated with significant skin penetration GHK-Cu is small enough to penetrate the stratum corneum (outer skin layer) in concentrations sufficient to activate regenerative processes

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The syringe needle is then to be inserted subcutaneously into the lower left abdominal area at a 45-degree angle through the abdominal muscles

Referenced with permission from the NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) for Small Cell Lung Cancer V.1.2026