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FIGURE 2 4 APAP-impacted human neurobehavior functions Increasing evidences data indicate APAP use during pregnancy may induce the potential risk of developing neurobehavior problems and hyperkinetic symptoms ( 5 APAP-induced hepatoxic effects Usually, most of patients take around 12 g or more APAP before inducing serious hepatotoxicity, and the peak serum transaminase activity can occur between 48 and 96 h

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The pathological features of AD are characterized by an enlarged and degenerative medial layer, vascular smooth muscle cell (VSMC) loss or dysfunction, proteoglycan accumulation, and collagen and elastic fiber cross-linked disorder and fragmentation [66]

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