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Chromatin immunoprecipitation sequencing analysis confirmed that the lactylation modification of histone H3K18 in CD4 + T cells directly activates FOXP3 gene expression by enriching in its promoter and enhancer regions, thereby promoting regulatory T cell differentiation

The native GHRH structure contains regions with suboptimal -helix probability, particularly at positions 8, 9, and 15, where competing -turn formation reduces structural stability

10.1016/j.expneurol.2023.114630 188 HuX.XuY.XuH.JinC.ZhangH.SuH.et al (2021)

doi: 10.3390/molecules29071552 468 GoudarziMGoudarziHRashidanM

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